Deaths from violence and injuries in South Africa are almost double the global average, while the death rate of South African women killed by their intimate partners is six times the world norm.
Some 3,5 million people seek healthcare for injuries, half of which are caused by violence.
Young men aged 15 to 29 are the most affected, both as victims and perpetrators, with seven times as many men than women dying in homicides.
The coloured population is also disproportionately affected by homicides.
Women were more likely to be killed by their male intimate partners than by strangers - especially those aged 14 to 44.
Some two-thirds of women murdered by their partners in the Western Cape had high alcohol levels in their blood, according to a study.
Child homicides are double those of other low income countries, with boys aged 10 to 14 most in danger of being killed.
More than 40 percent of men admitted to being physically violent towards their partners; 88 percent of Soweto women reported physical or psychological abuse by partners.
Although the murder rate in the country has been reduced, there has been little reduction in the rape rate, and a random population-based sample found that over a quarter of men (27,6 percent) admitted to having committed rape.
Most first raped before the age of 20, and half of these will rape again.
Up to 14 percent of men admit to taking part in gang rape.
In 2003 in Gauteng, one in 35 rape cases reported involved victims aged between one and three years old, while 40 percent were under 18.
Almost four in 10 girls report experiencing sexual violence before the age of 18, and most of this is not reported.
"Girls exposed to sexual abuse as young children are at increased risk of being raped again in childhood and of experiencing intimate partner violence as adults," note authors Professor Mohammed Seedat and colleagues.
"Boys who have been sexually abused in childhood are at risk of later becoming sexual abusers."
In addition, many children witness violence, with 35 to 45 percent of children having seen their mother being beaten.
Boys who witnessed this were more likely to beat their partners.
South Africa's road traffic death rate is also nearly double the global rate.
In 2007, four out of 10 traffic deaths were of pedestrians and deaths usually peaked over weekends.
Again alcohol played a prominent role in traffic deaths, with over half of pedestrian fatalities and almost half the drivers who killed them over the legal limit.
The authors estimate the "health and social cost" of alcohol misuse to be R9-billion a year.
Excessive speed was the main culprit in 30-50 percent of public passenger and heavy commercial accidents.
"Income inequality, low economic development and high levels of gender inequality are strong positive predictors of rates of violence and injury," note the authors.
The social dynamics that support violence are widespread poverty, unemployment, and income inequality; patriarchal notions of masculinity that valourise toughness, risk-taking, and defence of honour; exposure to abuse in childhood and weak parenting; access to firearms; widespread alcohol misuse; and weaknesses in law enforcement.
In addition, during apartheid there was very little common-law policing particularly in historically black areas, and some properly crimes were justified as "redistribution of wealth" and "in general, people resisted abiding by laws ... consequently lines between criminal and community were blurred and an ambiguity about enforcement emerged".
The "violence and injuries" paper was written by Mohamed Seedat, Ashley van Niekerk, Rachel Jewkes, Shahnaaz Suffla and Kopano Ratele. http://press.thelancet.com/saser5.pdf - IOL